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GS-441524

Product Overview

GS-441524 is a nucleoside analog antiviral precursor and the predominant active metabolite of Remdesivir. With the molecular formula C12H13N5O4 and a molecular weight of 291.26 g/mol, it functions as a potent inhibitor of RNA-dependent RNA polymerase (RdRp).

Supplied directly through a dedicated veterinary medical and diagnostic supply center with stable, large-scale inventory, this product supports commercial pharmaceutical formulators and veterinary product developers. Every batch is manufactured under strict chemical synthesis controls to ensure high stereochemical purity and minimal residual impurities, supporting direct scale-up from R&D to commercial manufacturing.

Product Specifications

Parameter	Standard Specification	Analytical Method
Chemical Name	(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile	IUPAC / CAS
CAS Number	1191237-69-0	-
Molecular Formula	C12H13N5O4	Elemental Analysis
Molecular Weight	291.26 g/mol	Calculated
HPLC Purity	>= 99.0% (Typical batch release: >= 99.5%)	High-Performance Liquid Chromatography
Appearance	White to off-white crystalline powder	Visual Inspection
Water Content (Karl Fischer)	<= 0.5%	Titrimetry
Residue on Ignition	<= 0.1%	Gravimetric Analysis
Individual Impurity	<= 0.1%	HPLC Area Normalization
Structural Identification	Confirmed by 1H-NMR and LC-MS	Spectrometry

Product Characteristics & Applications

Core Characteristics

Stereochemical Integrity: Controlled four defined stereocenters via asymmetric synthesis, preventing inactive stereoisomer carryover.
Low Bioburden Profile: Synthesized in a cleanroom environment, minimizing heavy metal catalysts and inorganic salt residues.
Solubility Profile: Freely soluble in DMSO (>= 58 mg/mL); restricted solubility in aqueous media requiring specific co-solvents (e.g., PEG300, Tween-80) for formulation development.

Target Applications

Veterinary Antiviral Formulations: Used as the core active pharmaceutical ingredient (API) intermediate for manufacturing therapeutic treatments targeting feline infectious peritonitis virus (FIPV).
Preclinical Research & Synthesis: Utilized as a reference standard and starting material in nucleoside chemistry and viral RNA synthesis inhibition studies.

Cat FIP GS-441524 Pill 25mg

Manufacturing & Quality Assurance

Synthesis & Purification Workflow
Our synthesis route utilizes multi-step fractional crystallization and preparative liquid chromatography separation to eliminate diastereomeric impurities.

Analytical Testing & Traceability
No batch leaves our facility without a full analytical release package. Each production lot is tested using:
Agilent HPLC Systems: For exact purity and impurity profile quantification.
Bruker 400MHz 1H-NMR: For molecular backbone verification.
LC-MS/MS: For accurate mass confirmation and trace byproduct screening.

Storage, Handling & Packaging

Storage Conditions

Powder Form: Store tightly sealed at -20°C in a dry, dark environment. Protect strictly from light, moisture, and high temperatures to prevent hydrolytic degradation.
Shelf Life: 24 months from the manufacturing date when stored under recommended unopened conditions.

Handling Precautions

Classified as an active pharmaceutical intermediate. Personnel must wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and a dust respirator, to avoid inhalation or dermal contact.

Packaging Specifications

Standard Packaging: Dual-layer packaging consisting of an inner food-grade low-density polyethylene (LDPE) bag, vacuum-sealed under nitrogen purge, placed inside an outer light-resistant aluminum foil bag and sealed in a rigid fiber drum.
Available Bulk Sizes: 100g, 500g, 1kg, 5kg, and 25kg containers. Custom packaging configurations available upon commercial agreement.

Frequently Asked Questions

Q: What purity specification is guaranteed for commercial bulk orders?

A: Our standard commercial grade maintains an HPLC purity of >= 99.0%, with typical production batches testing at >= 99.5%.

Q: Can you provide a Certificate of Analysis and full analytical spectra prior to dispatch?

A: Yes. Lot-specific analytical data, including the Certificate of Analysis, HPLC chromatograms, and 1H-NMR spectra, can be reviewed during the sample evaluation or order confirmation phase.

Q: What are the recommended storage parameters to prevent degradation?

A: Store the solid powder in its original sealed container at -20°C, protected from direct light and atmospheric moisture. Avoid prolonged exposure to ambient room temperature or high humidity.

Q: What is the standard packaging configuration for kilogram-scale shipments?

A: Kilogram quantities are packed in vacuum-sealed double LDPE bags under a nitrogen atmosphere, enclosed in foil laminate bags, and housed in heavy-duty fiber drums to ensure moisture and light barrier protection during international shipping.

Q: Are evaluation samples available for new client qualification?

A: Yes. We support small-quantity trial orders (ranging from 1g to 100g) for laboratory analytical evaluation and formulation compatibility testing prior to committing to commercial bulk procurement.

Q: What is the standard lead time for bulk orders ranging from 5kg to 25kg?

A: In-stock standard batches ship within 3 to 5 business days following payment and compliance verification. For scheduled regular call-off orders, inventory is reserved in our climate-controlled warehouse under pre-arranged supply contracts.

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