Mechanism of Action of Capromorelin
Capromorelin works by acting as a ghrelin receptor agonist, mimicking the natural "hunger hormone" ghrelin to stimulate appetite in pets. By activating ghrelin receptors in the brain-particularly in the hypothalamus-it triggers normal hunger signals and encourages food intake. At the same time, Capromorelin increases the release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which support metabolism, muscle maintenance, and overall energy levels. Through this dual action, Capromorelin effectively helps pets with anorexia or poor appetite regain interest in eating and improve their nutritional status.
Strength/Concentration
Each tablet contains 10 mg of Capromorelin, providing precise and effective dosing for pets of various sizes. The bottle contains 100 tablets, ensuring a sufficient supply for long-term use under veterinary guidance.
Advantages of Capromorelin
Clinically Proven Appetite Stimulation
Capromorelin effectively increases appetite in dogs and cats by mimicking the natural hunger hormone (ghrelin), helping pets eat more and regain weight.
01
Improves Weight Gain and Nutritional Intake
By stimulating hunger and promoting food consumption, it supports healthy weight recovery in pets experiencing weight loss due to illness, aging, or stress.
02
Enhances Overall Energy and Well-Being
Increased food intake often leads to improved energy levels, strength, and activity, supporting better quality of life.
03
Easy Oral Administration
The medication is simple to give as an oral liquid or tablets, making it convenient for long-term or short-term use.
04
Fast Onset of Action
Many pets show improved appetite within hours of the first dose, providing quick support during periods of reduced food intake.
05
Potential Side Effects of Capromorelin
Capromorelin is generally well-tolerated, but some pets may experience mild to moderate side effects, including:
- Vomiting or nausea
- Diarrhea
- Increased drinking and urination
- Drooling
Most side effects are temporary and resolve on their own. If your pet shows severe or unusual symptoms, contact your veterinarian immediately.
Contraindications for Capromorelin
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Capromorelin should NOT be used in pets that:
- Are allergic or sensitive to Capromorelin or any of its ingredients
- Have severe kidney or liver disease, unless closely monitored by a veterinarian
- Are pregnant or nursing, as safety has not been established
- Are debilitated or have uncontrolled systemic illness without veterinary supervision
Use with caution in pets that:
- Have heart disease, as increased fluids and hormone changes may affect cardiac function
- Have diabetes, because it can influence glucose and insulin dynamics
- Are taking medications that may affect kidney function, appetite, or hormone regulation
Always consult a veterinarian before starting Capromorelin to ensure it is safe based on the pet's medical history and concurrent medications.
Drug Interactions with Capromorelin
Capromorelin can interact with several medications, potentially altering how either drug works or increasing the risk of side effects. The following drugs are known or suspected to interact with Capromorelin:
- Amiodarone
- Diltiazem
- Cimetidine
These medications may affect the metabolism of Capromorelin or be affected by it, which can change blood drug levels.
To ensure safety:
- Always inform your veterinarian about all medications, supplements, vitamins, or herbal products your pet is currently taking.
- Your veterinarian may still prescribe Capromorelin alongside these drugs but may adjust the dosage or monitor your pet more closely for any unusual reactions.
If your pet shows any unexpected symptoms while taking Capromorelin with other medications, contact your veterinarian immediately.
Cautions
For oral use in cats and dogs only. Do not use in pets that have a hypersensitivity to capromorelin, or in pets with hypersomatotropism (acromegaly). It may increase serum glucose for several hours after dosing; use in pets with current or historical diabetes mellitus has not been evaluated and may not be appropriate. Use with caution in pes that may have cardiac disease, severe dehydration, or hepatic dysfunction. Capromorelin has not been evaluated in pets younger than 5 months of age, or in breeding, pregnant or lactating pets.
Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.
Storage
Store at or below 86°F in controlled room temperature. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.
Dosage & Administration of Capromorelin
Capromorelin is given orally to stimulate appetite, and the exact dose is determined based on your dog's body weight. Follow your veterinarian's instructions closely.
Determine the Correct Dose
- Weigh your dog in kilograms (kg).
If the weight is in pounds (lbs), convert it by dividing by 2.2.
Example: 22 lb ÷ 2.2 = 10 kg.
- Calculate the required dosage:
Recommended dose: 3.0 mg per kilogram (3.0 mg/kg).
Example: 10 kg × 3.0 mg/kg = 30 mg.
- Determine the number of tablets needed:
Each tablet contains 10 mg of Capromorelin.
Example: 30 mg → 3 tablets.
How to Administer
- Give the tablet by mouth, exactly as prescribed by your veterinarian.
- If your pet eats on a schedule, offer food 30 minutes after administration to support appetite stimulation.
- If vomiting occurs within 15 minutes, or if only part of the dose was swallowed, the dose may be safely re-administered.
Additional Tips
- Capromorelin can be given with or without food, but pairing with food may help minimize stomach upset.
- Make sure your pet has access to fresh water at all times.
- Continue the treatment for the duration recommended by your veterinarian, even if appetite improves quickly.
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